The University of Toledo
Chemical and Environmental Engineering (MS 305)
3056 Nitschke Hall
1650 N Westwood Ave
Toledo, Ohio 43606-3390
2006 Ph.D. Chemical Engineering, University of Delaware
2001 B.Ch.E., University of Minnesota
2001 B.S. Chemistry, University of Minnesota
Current research interests focus on the design, characterization and application of biopolymer-based soft materials. These include the self-assembly of bioderived surfactant/polyelectrolyte mixtures, stimulus-responsive micro- and nanoparticles and gels, and drug delivery.
Recent advances in chemical product design, medicine and nanotechnology have ushered in a new age of “smart” materials that respond to external stimuli such as changes in pH, ionic strength or temperature, and mechanical or electromagnetic perturbations. Bioderived polyelectrolytes (e.g., cellulose derivatives, chitosan and alginate) are commonly used as sustainable building blocks for these materials and find countless applications in foods, cosmetic product formulations, controlled release, biomaterials, medical imaging, sensors, fuel cells and water treatment. Despite their broad use, however, many applications of these materials are limited by the lack in understanding of their physicochemical properties and the design variables that control them.
To this end, the goals of our research are to:
advance the mechanistic understanding of the molecular, colloidal and macroscopic properties of biopolyelectrolyte-based materials and
to apply this understanding towards furthering their use in areas such as pharmaceutics, MEMS and consumer product formulations.
Specifically, we are currently investigating: sustainable materials from bioderived surfactant-polyelectrolyte mixtures, biopolyelectrolyte-based pharmaceutical colloids, and directed assembly of “smart” polyelectrolyte complex microstructures and microdevices.
Huang, Y.; Lapitsky, Y. Monovalent salt enhances colloidal stability during the formation of chitosan/tripolyphosphate microgels. Langmuir (in press) doi:10.1021/la201194a (2011).
Worthen, A.J.; Lapitsky, Y. Stabilization of bioderived surfactant/polyelectrolyte complexes through surfactant conjugation to the biopolymer. Colloid Polym. Sci. 289, 1589-1596 (2011).
Wang, Y.; Cooke, M.J.; Lapitsky, Y.; Wylie, R.G.; Sachewsky, N; Corbett, Morshead, C.M.; Shoichet, M.S. Transport of epidermal growth factor in the stroke-injured brain. J. Controlled Release 149, 225-235 (2011).
Chen, Y.; Lapitsky, Y. Interactions of anionic surfactants with cationic polyelectrolyte gels: Competitive binding and application in separation processes. Colloids Surf. A 372, 196-203 (2010).
Wang, Y.; Lapitsky, Y.; Kang, C.E.; Shoichet, M.S. Accelerated release of a sparingly soluble drug from an injectable hyaluronan–methylcellulose hydrogel. J. Controlled Release 140, 218-223 (2009).
Ho, K.; Lapitsky, Y.; Shi, M. Shoichet, M.S. Tunable immunonanoparticle binding to cancer cells: thermodynamic analysis of targeted drug delivery vehicles. Soft Matter 5, 1074-1080 (2009).
Lapitsky, Y.; Zahir, T.; Shoichet, M.S. Modular biodegradable biomaterials from surfactant and polyelectrolyte mixtures. Biomacromolecules 9, 166-174 (2008).
Lapitsky, Y.; Parikh, M.; Kaler, E.W. Calorimetric determination of surfactant-polyelectrolyte binding isotherms. J. Phys. Chem. B 111, 8379-8387 (2007).
Lapitsky, Y.; Eskuchen, W.J.; Kaler, E.W. Surfactant and polyelectrolyte gel particles that swell reversibly. Langmuir 22, 6375-6379 (2006).
Lapitsky, Y.; Kaler, E.W. Formation and structural control of surfactant and polyelectrolyte gels. Colloids Surf. A 282-283, 118-128 (2006).